I voted for a full wipe. I think it should be far enough in the future to ensure the death of every character has come and gone, adventurers have thwarted any liches' attempts at immortality by then, and the most epic of the heroes and places are now legends and spots on a map. At the very least anyone who could potentially still be alive in the new world are simply NPCs.
If people are allowed to recreate their same character from level one, what is the point of wiping them in the first place? The second incarnation of Layo should be an opportunity to start over completely fresh.